Drug induced thrombocytopenia ppt?

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Date created: Mon, Jun 28, 2021 8:53 AM

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❔ Drug induced thrombocytopenia?

Drug-induced thrombocytopenia (DIT) is a relatively common clinical disorder. It is imperative to provide rapid identification and removal of the offending agent before clinically significant bleeding or, in the case of heparin, thrombosis occurs.

❔ Drug induced thrombocytopenia list?

Hundreds of drugs have been implicated in its pathogenesis, among those, drugs most often associated with DITP are: heparin, cinchona alkaloid derivatives (quinine and quinidine), penicillin, sulfonamides, non-steroidal anti-inflammatory drugs (NSAIDs), anticonvulsants, antirheumatic and oral antidiabetic drugs, gold salts, diuretics, rifampicin and ranitidine [23–27]; several other drugs are occasionally described in case reports of thrombocytopenia [28;29].

❔ Drug induced thrombocytopenia treatment?

Thus, the primary treatment for drug-induced thrombocytopenia is to discontinue the suspected causative agent. Patients experiencing life-threatening bleeding may benefit from intravenous immunoglobulin (IVIG) therapy, plasmapheresis, or platelet transfusions [9;10]. Corticosteroids seem inefficient in the treatment of DIT .

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DRUG-INDUCED THROMBOCYTOPENIA James N. George, M.D. EHA Working Group on Thrombocytopenias June 10, 2004 Drug-Induced Thrombocytopenia Frequency is uncertain ... – A free PowerPoint PPT presentation (displayed as a Flash slide show) on PowerShow.com - id: 42c61e-YWI0M

Drug induced thrombocytopenia Development of thrombocytopenia after quinine was first described by Vipan in 1865, and since then a large number of drugs have been found to cause thrombocytopenia. Drug-induced thrombocytopenia generally affects only a small percentage of patients taking a particular drug, and is usually not severe, although it ...

Fahey VA. Heparin-induced thrombocytopenia. J Vasc Nurs . 1995;13(4):112-116. 2. Warkentin TE, Levine MN, Hirsh J, et al. Heparin-induced thrombocytopenia in patients treated with low- molecular-weight heparin or unfractionated heparin. N Engl J Med. 1995;332(20):1330-1335. 3. Warkentin TE, Kelton JG. A 14-year study of heparin-induced ...

7 Drug-Induced Thrombocytopenia • Diagnosis as an imperfect science • Timing of thrombocytopenia in the context of clinical picture ‒Other clinical explanations ‒Prior platelet counts ‒Potential offending agents? • Splenic sequestration ‒All normal splenic functions accentuated in the enlarged spleen ‒Typically affects the platelets and the WBC

DRUG-INDUCED THROMBOCYTOPENIA - DRUG-INDUCED THROMBOCYTOPENIA James N. George, M.D. EHA Working Group on Thrombocytopenias June 10, 2004 Drug-Induced Thrombocytopenia Frequency is uncertain ... | PowerPoint PPT presentation | free to view

Drug-induced thrombocytopenia (DIT) is a relatively common clinical disorder. It is imperative to provide rapid identification and removal of the offending agent before clinically significant bleeding or, in the case of heparin, thrombosis occurs. DIT can be distinguished from idiopathic ...

Certain drugs have been shown to directly mediate an antibody-independent platelet apoptosis by causing Ca+2 signaling, mitochondrial depolarization, and phosphatidylserine exposure in platelets (). 4,5 Although these findings sound interesting, not all patients treated with these drugs experience some degree of thrombocytopenia.Hence, the clinical evidence that drug-induced apoptosis might be ...

In this issue of Blood, Tochigi et al made it their mission to understand the molecular mechanisms by which immunomodulatory drugs (IMiDs) induce thrombocytopenia. The authors use a combination of in vitro and ex vivo methods to show that treatment regimens, including IMiDs in multiple myeloma (MM), lead to aromatase degradation in human megakaryocytes.

Thrombocytopenia is one of the most commonly observed drug-induced adverse hematologic toxicities in the clinic. Therefore, in vitro and in vivo evaluations of effect of drugs on platelets are an important component in preclinical safety assessment in drug development. To date, a number of mechanisms have been identified to be associated with drug-mediated thrombocytopenia.

Drug-induced thrombocytopenia is the most common drug-induced hematologic disorder, with reports suggesting that between 0.1% and 5% of patients who receive heparin develop heparin-induced thrombocytopenia (HIT). 2,3 The Berlin Case-Control Surveillance Study was conducted from 2000 to 2009 to assess the incidence and risks of drug-induced ...

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Can a statin drug cause thrombocytopenia?

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Myopathy, rhabdomyolysis, and liver enzyme abnormalities are rare, but major side effects seen with statin use [5,6]. A few case reports of statin-induced thrombocytopenia, specifically with atorvastatin, rosuvastatin, and simvastatin [7-15]. Thrombocytopenia can be either inherited or acquired.

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What drug causes thrombocytopenia in elderly?

Thrombocytopenia (or low platelet count) is a common hematologic abnormality encountered in older adults ommon causes of thrombocytopenia include (Table 1): …

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Drug induced abnormalities?

Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.

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Drug induced acne?

Drug-induced acne. A variety of drugs may provoke acne, with drug-induced acne (DIA) often having some specific clinical and histopathologic features. DIA is characterized by a medical history of drug intake, sudden onset, and an unusual age of onset, with a monomorphous eruption of inflammatory papules or papulopustu ….

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Drug induced anemia?

Drug-induced anemia includes many kind of anemias with different mechanisms. Mechanisms of drug-induced anemia are divided into two groups, namely erythrocyte injury in peripheral blood and damage of erythroid progenitor cells or erythroblasts. Hemolytic anemias are included in the former and megaloblastic anemia, ringed sideroblastic anemia and ...

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Drug induced angioedema?

Angioedema (AE) is the end result of deep dermal, subcutaneous and/or submucosal swelling, and represents a major criterion in the definition of anaphylaxis. Drug-induced AE, like other cutaneous drug reactions, is most frequently elicited by betalactam

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Drug induced anorexia?

Mechanisms of drug-induced anorexia Inhibition of dopamine and serotonin reuptake Increase of satiety-inducing hypothalamic neurotransmitters 8 Endogenous digoxin-like factor disruption Abnormal serum leptin levels Taste alternation Drug-induced nausea or vomiting

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Drug induced bipolar?

Drug induced bipolar disorder reflects the relationship between certain substances and how they impact brain chemistry. In some instances, stopping a prescription medication may spark mania and depressive episodes, as the

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Drug induced cholestasis?

Cholestasis caused by drugs is an important differential diagnosis in patients presenting with a biochemical cholestatic pattern. The extent of serologic tests and radiological imaging depends on the clinical context. The underlying condition of the patient and detailed information on drug use, results of rechallenge, and the documented ...

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Drug induced coagulopathy?

Neuroleptic drug-induced coagulopathy: mechanism of reaction and duration of effect. Zengotita HE, Holt RJ. Patients (N = 32) with documented phenothiazine-induced reductions in platelet levels were evaluated after drug substitution with haloperidol; 28 (88%) patients had normal platelet levels after 1 year of treatment with haloperidol.

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Drug induced coma?

A drug-induced coma puts a person into a deep state of unconsciousness, which allows the brain to rest and thus decreases its swelling. The decrease in swelling can result in less pressure being put on the brain, which lessens the risk of damaging effects.

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Drug induced delirium?

drug induced amnesia drug induced dementia

Drugs can cause any of the three types of delirium: hyperactive, hypoactive, and mixed delirium. Both hyperactive and mixed delirium are commonly seen in cholinergic toxicity, alcohol intoxication, certain illicit drug (stimulant) intoxication, serotonin syndrome, alcohol and benzodiazepine withdrawal.

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Drug induced dementia?

Medication-induced dementia is a cognitive impairment of language, memory, and comprehension originating from or complicated by prescription or over-the-counter (OTC) medications. With the wide range of possible drugs that could contribute to the condition and the variance of symptoms, it is difficult to gather concrete evidence for the condition.

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Drug induced depersonalization?

Drug-induced Depersonalization Disorder (DPD) is very common, and as stronger strains become more popular, Depersonalization from weed is becoming incredibly frequent. The most common situation is that you've had an bad experience or panic attack while on weed (or cannabis, LSD, ketamine etc) and now: I'm still high the next day

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Drug induced depression?

Evidence was found linking corticosteroids, interferon-alpha, interleukin-2, gonadotropin-releasing hormone agonists, mefloquine, progestin-releasing implanted contraceptives and propranolol to the etiology of atypical depressive syndromes. Conclusions: A small number of drugs have been shown capable of inducing depressive symptoms.

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Drug induced dyskinesia?

Drug induced dyskinesia is an involuntary movement disorder. Signs and symptoms include repetitive and irregular motions of the mouth, face, limbs and/or trunk. [1] Treatment with antipsychotic drugs and levodopa (commonly used to treat Parkinson disease ) are well recognized causes of drug-induced dyskinesia.

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Drug induced dyspepsia?

drug therapy drug induced parkinsonism mechanism

Functional dyspepsia is the term used for patients when endoscopy and other diagnostic tests have ruled out organic pathology. The most common drugs that cause dyspepsia include aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs), which can contribute to mucosal damage, ulceration, and bleeding complications.

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Drug induced epilepsy?

Drug-induced seizures are a commonly encountered problem for physicians. In this article, drugs that cause seizures are discussed with regards to the incidence of seizures, associated clinical factors, risk factors, and special treatment considerations. This information should help physicians determ …

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Drug induced esophagitis?

Drug or pill-induced esophagitis is esophageal mucosal injury caused by the medications and usually refers to a direct toxic effect on esophageal mucosa by the culprit medication. Common symptoms include retrosternal pain, dysphagia, or odynophagia.

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Drug induced fever?

Drug-induced fever is most commonly the result of a hypersensitivity reaction and its characteristics resemble those of an allergic reaction. The fever most commonly occurs after 7 to 10 days of drug administration, persists as long as the drug is continued, disappears soon after stopping the drug, and will rapidly reappear if the drug is restarted.

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Drug induced hallucinations?

Hallucinations / chemically induced* Humans Male Promethazine / adverse effects*

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Drug induced hives?

The most common type of drug reaction is hives, also known as urticaria. They are raised, swollen, red or flesh-colored bumps or welts that appear on the skin. They can take on many shapes and can be very itchy. They usually develop in groups and may cover large areas of skin.

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