How does polypharmacy affect drug therapy efficacy and overall health?

Asked By: Harmony Fisher
Date created: Sun, Jan 31, 2021 5:27 PM
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Unfortunately, there are many negative consequences associated with polypharmacy. , Specifically, the burden of taking multiple medications has been associated with greater health care costs and an increased risk of adverse drug events (ADEs), drug-interactions, medication non-adherence, reduced functional capacity and ...
Answered By: Gustave Shields
Date created: Mon, Feb 1, 2021 7:30 PM

Why are american health care costs so high?

Why are american health care costs so high?
One of the biggest drivers of polypharmacy is that clinicians tend to look at the medications they prescribe and patients’ health conditions in separate silos. Clinicians would reach very different conclusions about the wisdom of prescribing certain therapies if they considered a patient’s overall medical profile.
Polypharmacy may lead to increased bleeding risk by increasing the possibility of drug–drug interactions, by direct effect of some medications (including OACs, platelet inhibitors, and NSAIDs), or by increasing the risk of fall‐related bleeding (due to sedatives and antihypertensive medications). 24 Polypharmacy is also a marker of higher comorbidity burden and frailty, and despite extensive covariate adjustment, the observed increased risk of bleeding may be due to ...
drug–drug interactions may account for these complications, the regimen complexity that accompanies polypharmacy may also negatively affect adherence [6]. Currently, patients with AFwhorequireanticoagulanttherapyeitherreceivevitaminK antagonists (of which “warfarin” is typically used in most countries) or non-vitamin K oral anticoagulants (DOACs).
Additionally, older patients are generally treated with polypharmacy regimens, which increase the likelihood of drug–drug interactions when the prescription of an antimicrobial agent is needed. A progressive impairment in the functional reserve of multiple organs may affect either pharmacokinetics or pharmacodynamics during aging.
Polypharmacy is common in patients with atrial fibrillation and presents a challenge given the risk of medication interactions which in turn may affect the safety and efficacy of antithrombotic therapy.
Polypharmacy is a barrier to adherence because of the associated complex medication regimens, increased risk of adverse drug events and high medication costs. Poor adherence contributes to the increased risk of medication errors seen with polypharmacy. Polypharmacy is associated with suboptimal prescribing.
Whilst healthcare professionals are reliant on good health systems to enable them to work well with people under their care and identify those at risk of problematic polypharmacy; ultimately at some point a medication review will be conducted in order to assess what the medicines are being used for, how well treatment goals are being achieved, including looking at any issues and concerns that people taking medicines may have.
The primary reason for this is the advent of psychopharmacology that is receptor specific-based rather than a disorder-based medication. 2. Although polypharmacy is often used in the management of psychiatric disorders, there is very poor awareness of its efficacy. In some situations, polypharmacy also lacks respect and acceptability.
Polypharmacy is a silent syndrome that often presents as functional and cognitive impairment, a new diagnosis, or treatment failure. Most health care providers recognize that polypharmacy is increasingly prevalent and have the understanding that it may be impairing optimal outcomes, yet, many health…
This polypharmacy results in drug interactions and adverse effects that are often overlooked in clinical practice. Furthermore, elderly people have been excluded from most cardiovascular drug trials. Thus, there is limited randomized trial data on the use of these medications in this age group.
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Drugs interfere with the way neurons send, receive, and process signals via neurotransmitters. Some drugs, such as marijuana and heroin, can activate neurons because their chemical structure mimics that of a natural neurotransmitter in the body. This allows the drugs to attach onto and activate the neurons.
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